Effect of Mechanoactivation on The Structure, Physical, Chemical and Biological Properties of Calcium Lactate, Calcium Gluconate and Calcium Citrate

Abstract

The influence of mechanical activation on calcium lactate, gluconate and citrate structure, dissolution rate, angle of polarization plane of water solutions and microelectrophoretic mobility of erythrocytes and buccal cells in water solutions was studied. Plate-like particles of mechanically activated powder are collected in aggregates of particles. Thickness and sizes of particles depends on the mechanical activation regimes. Such activation results in amorphization of crystal calcium lactate and crystallization of amorphous calcium lactate. The difference of structural state of initial and activated salts remains in water solutions. Angles of polarization plane of mechanoactivated calcium gluconate and calcium lactate water solutions are less than those of initial salts. The increased amount of active buccal cells in solutions of calcium lactate with the lower angle of rotation of polarization plane was observed. However the percentage of active erythrocytes and their vibration amplitude is conversely decreased. Opposite to calcium lactate, less optically active modification of calcium gluconate shows more bio-activity both to buccal cells and erythrocytes. Biological activity of mechanoactivated samples of calcium lactate and calcium gluconate, caused by optical isomerism, returns to the bio-activity level of initial samples at ambient condition during 12 month. Crystal structure of calcium citrate remained unchanged. Water solutions of calcium citrate are not optically active.