Effect of ESRD on Concentration of Serum Creatinine, Urea and Glucose in Male Patients

Abdounasser Albasher Omar, Rima Rajap Aboud, Wijdan Albakoush, Rabia Amar Anwesre


There is a limited number of studies about end-stage renal disease (ESRD) in Libya. So, this study was carried out to inspect the effect of ESRD on the concentration of three biochemical parameters in blood serum. Concentrations of serum creatinine (SCr), serum glucose (SGlu) and serum urea (SUr) were measured in 30 males with ESRD and in 30 normal males. SCr and SUr mean values in patient group were found to be higher than the reference interval, and higher than the critical value, too. SGlu mean value was higher than the reference interval, but within the critical interval. Comparison of SCr, SUr and SGlu means, by applying the t-test, revealed significant differences (P < 0.01) between patient group and control group. Some significant relationships (P < 0.05) were found between the study parameters in patient group but not in the control group. Similarly, the significant relationships (P < 0.05) found in control group were not recorded in the patient group. These differences in relationships were accompanied by differences in similarity according to the results of cluster analysis. Briefly, the results reflected the effect of ESRD on SCr, SUr and SGlu concentrations.


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A. Staples and C. Wong, “Risk Factors for Progression of Chronic Kidney Disease,” Curr Opin Pediatr, vol. 22, no. 2, pp. 161–169, Apr. 2010. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948868/.

R. Thomas, A. Kanso and J. R. Sedor, “Chronic Kidney Disease and its Complications,” Primary Care, vol. 35, no. 2, pp. 329-344, Jun. 2008. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474786/.

D. D. Murphree and S. M. Thalen, “Chronic Kidney Disease in Primary Care,” J Am Borad Fam Med, vol. 23, no. 4, pp. 542-550, July-Aug. 2010. Available: http://www.jabfm.org/content/23/4/542.long.

National Kidney Foundation, “K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification,” Am J Kidney Dis, vol. 39. 2 Supple 1, S1–266, 2002.

A. A. Hassanien, A. Majeed, H. Watt and N. Basri, “Review of Pre end-stage Renal Disease Care in the Western Region in Saudi Arabia,” Journal of Diabetes Research and Clinical Metabolism, vol. 2, no. 12, pp. 1-7, 2013. Available: http://www.hoajonline.com/jdrcm/2050-0866/2/12.

A.S. Levey, J. Coresh, E. Balk et al., “National Kidney Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, classification, and stratification,” Ann Intern Med, vol. 139, pp. 137–147, July 2003.

Available: http://annals.org/article.aspx?articleid=716575.

N. Amin, R. T. Mahmood, M. J. Asad, M. Zafar and A. M. Raja, “Evaluating Urea and Creatinine Levels in Chronic Renal Failure Pre and Post Dialysis: A Prospective Study,” JCvD, vol. 2, no.4, pp. 182-185, Apr. 2014.

Available: http://www.researchpub.org/journal/jcvd/number/early/22.pdf.

N. A. A. Mohamed, J. M. ELhafiz and F. B. M. Ahmed, “Serum Creatinine in Normal Sudanese Athletes and Soldiers,” AJCMR, vol. 2, no. 4, pp. 84-86, 2014. Available: http://pubs.sciepub.com/ajcmr/2/4/5/.

S. Gowda, P. B. Desai, S. S. Kulkarni, V. V. Hull, A. A. K. Math and S. N. Vernekar, “Markers of Renal Function Tests,” N Am J Med Sci, vol. 2, no. 4, pp. 170–173, Apr. 2010. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354405/.

J. E. Gerich, “Role of the Kidney in Normal Glucose Homeostasis and in the Hyperglycaemia of Diabetes Mellitus: Therapeutic Implications.” Diabetic Med, vol. 27, pp. 136–142, Feb. 2009. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232006/.

A. Alcelik; M. Tosun; M. F. Ozlu et al., “Serum Levels of Omentin in End-Stage Renal Disease Patients,” Kidney Blood Press Res, vol, 35, no. 6, pp. 511-516, 2012. Available: http://www.karger.com/Article/FullText/338796.

R. Freethi, A. V. Raj, K. Ponniraivan, M. R. Khan, A. Sundhararajan and Venkatesan, “Study of Serum Levels of Calcium, Phosphorus and Alkaline Phosphatase in Chronic Kidney Disease,” Int J Med Res Health Sci, vol. 5, no. 3, pp. 49-56, 2016.

Available: http://ijmrhs.com/study-of-serum-levels-of-calcium-phosphorus-and-alkaline-phosphatase-in-chronic-kidney-disease/.

R. Himansu, B. Prithwijit, D. Subhasish, R. Musfikur, S. Mohua and B. Chiranjeet, “Insulin Resistance in End Stage Renal Disease (ESRD) Patients in Eastern India: A Population Based Observational Study,” Journal of Drug Delivery & Therapeutics, vol. 4, no. 1, pp. 127-130, 2014. Available: http://jddtonline.info/index.php/jddt/article/view/762/454.

A. Azab and M. O. Albasha, “Physiological Changes during Renal Failure in Chronic Renal Failure Patients in Al Zahra Kidney Surgery Hospital (In Arabic),” Journal of education faculties in Azzawia University, Issue 3, 2015.

K. S. Merzah and S. F. Hasson, “The Biochemical Changes in Patients with Chronic Renal Failure,” Med. Biol. Sci, vol. 4, no. 1, pp. 75-79, Jan. 2015. Available: http://www.ijpmbs.com/uploadfile/2015/0427/20150427055327735.pdf.

M. Sathishbabu and S. Suresh, “A Study on Correlation of Serum Prealbumin with Other Biochemical Parameters of Malnutrition in Hemodialysis Patient,” Int J Biol Med Res, vol. 3, no. 1, pp. 1410-1412, 2012.


F. A. Goleg, N. C. Kong and R. Sahathevan, “Dialysis-treated End-stage Kidney Disease in Libya: Epidemiology and Risk Factors,” Int Urol Nephrol, vol. 46, no. 8, pp. 1581-1587, Aug. 2014. Available: http://link.springer.com/article/10.1007%2Fs11255-014-0694-1.

W. A. Alashek, C. W. McIntyre and M. W. Taal, “Epidemiology and Aetiology of Dialysis-treated End-Stage Kidney Disease in Libya,” BMC Nephrol, Vol. 13, no. 33, Jun. 2012. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407761/.

K. A. Akkari, “Projecting Requirements for End Stage Renal Disease Services in Libya 2014-2024,” Ibnosina J Med B S, vol. 5, no. 6, pp. 354-362, 2013. Available: http://journals.sfu.ca/ijmbs/index.php/ijmbs/article/view/461/764.

C. A. Burtis, E. R. Ashwood and D. E. Bruns, Tietz Text Book of Clinical Chemistry and Molecular Diagnostics, 4th edition, Elsevier, Chapter 45, pp. 836-873, 2006.

Z. A. M. Al-Jawadi, “Clinical and biochemical study of acute renal failure disease,” NJC, vol. 21, pp. 119-124, 2006.

Available: www.uobabylon.edu.iq/publications/chemistry_edition5/njc5_publication_3.DOC.

H. A. Hassan, “Measurement of Some Biochemical Values in Hemodialysis Patients in Baghdad,” Iraqi J Pharm Sci, vol. 23, no. 1, pp. 14-18, 2014. Available: http://bijps.com/News_Details.php?ID=146.

D. A. Kadhem, A. K. Abed, H. A. Abedel-Salam and A. Abrahem, “Study Some Biochemical Parameters of Chronic Kidney Failure Patients in Karbala gove./Iraq (In Arabic),” J.Thi-Qar Sci, vol. 4, no. 1, pp. 80-89, Sep. 2013.

Available: http://iasj.net/iasj?func=fulltext&aId=83309.

S. B. Airaf and S. H. Khorshid, “Level of Renin Enzyme, α-L-Fucose and Some Biochemical Markers for Chronic Renal Failure Patients (In Arabic),” Tikrit Journal of Pure Science, vol. 18, no. 5, pp.151-157, 2013. Available: http://iasj.net/iasj?func=fulltext&aId=83809.


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MAYFEB Journal of Chemistry and Chemical Engineering


Toronto, Ontario, Canada

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